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. 2011 Sep 21;302(1):C67–C76. doi: 10.1152/ajpcell.00225.2011

Fig. 2.

Fig. 2.

Inhibition of short-circuit current (Isc) by CFTR inhibitors in primary cultures of shark rectal gland (SRG) tubular epithelial cells. A: summary of mean % inhibition with 10 μM CFTRinh-172 (n = 8), 300 μM glibenclamide (n = 3), and 90 μM GlyH-101 (n = 4). After stimulation with C-type natriuretic peptide (CNP) and forskolin, CFTRinh-172 inhibited to only 4.0 ± 1.3%, glibenclamide to 54 ± 7.42%, and GlyH-101 to 64 ± 3.9%. The inhibition by glibenclamide and GlyH-101 is highly significant (***P < 0.001) compared with CFTRinh-172. Values represent means ± SE. B–D: representative Isc recordings with CFTRinh-172 (B), glibenclamide (C), and GlyH-101 (D).