Fig. 8.

Logarithmic dose response demonstrating relative insensitivity of sCFTR (n = 7) vs. hCFTR (n = 11) to inhibition by CFTR_inh-172 (A) and relative insensitivity of pCFTR (n = 11) vs. hCFTR (n = 8) to inhibition by glibenclamide (B). All values are means ± SE. The mean maximum inhibition by CFTR_inh-172 was 73 ± 7.4% (IC₅₀ = 10.3 μM) for hCFTR and 10.3 ± 2.5% (IC₅₀ = 251 μM) for sCFTR. The mean maximum inhibition by glibenclamide was 74.4 ± 4.2% (IC₅₀ = 102 μM) for hCFTR and 18.4 ± 4.4% (IC₅₀ = 930 μM) for pCFTR.