Figure 4:

Long-term potentiation (LTP) experiment indicating stable baseline responses were recorded in hippocampal area CA1 of slices from both groups for 20 min. LTP-inducing high frequency stimulation (HFS) consisted of one train of HFS (100 pulses at 100 Hz). Perfusion with vehicle (0.1% dimethyl sulfoxide, DMSO) resulted in rapid and long-lasting potentiation. The group treated with 0.008% M. speciosa Korth standardised methanol extract dissolved in 0.1 % DMSO showed inhibition of the induced long-term potentiation, a short-term potentiation. The initial slope of the field excitatory post-synaptic potential (fEPSP) has been normalised to the average baseline value during the perfusion. The points represent means, and the error bars represent SEM (n = 6, respectively).