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Mitophagy as a response to stress. Stress signals (red), arising from outside (extrinsic) or within (intrinsic) the mitochondrion, interact with regulatory intermediates in the cell. These intermediates coordinate the cell's response to these stresses, in this case promoting the removal of excess or dangerous mitochondria. As a consequence, mitochondria are then removed by an autophagic mechanism, mitophagy. Hypothesised, but as yet unconfirmed, stressors are indicated by “?”.
