Table 2.
Contrasting observations in yeast mitophagy research.
| Observation | Supporting studies | Contradicting studies |
|---|---|---|
| Depolarisation triggers mitophagy | [51, 52] | [55] |
| Fission precedes mitophagy | [52] | [55] |
| Mitophagy by microautophagy (micromitophagy) | [42] | |
| Stress and regulation of mitophagy | ||
| -TOR | [41, 55] | |
| -MAPK | [54] | |
| -Redox | [53] | |
| -RTG | [44] | [45, 48]* |
| -General stress | [55] | |
| -pH | [63] | |
| Proteins required for mitophagy | ||
| -Uth1p | [41, 42] | [45, 48]* |
| -Aup1p | [43] | [45, 48]* |
| -Atg32p | [45, 48] | |
| -Atg33p | [48] | |
| Requirement of nonrespiratory medium to induce mitophagy under N-starvation | [38, 48]† | [42, 52, 97] |
*These studies reported no evidence of involvement, but did not directly contradict the observation.
†In this study, limited mitophagy is demonstrated during lactate-supplemented N-starvation.