Table 3.

ANOVA-Derived Main Effect of Drug on Brain Response to Emotional Faces

Contrast	Region	Laterality	Size (mm3)	Z Score	MNI Coordinates
					x	y	z
Angry > Neutral	Middle Frontal Gyrus	R	536	4.33	32	36	22
		R	136	3.94	36	38	2
		R	272	3.54	30	50	−10
		L	152	3.39	−40	56	2
	Caudate	L	384	4.11	−20	−14	24
	Precuneus	L	312	4.03	−12	−54	52
		R	280	3.37	18	−50	50
	Precentral Gyrus	R	456	4.02	14	−22	78
		R	104	3.42	28	−10	56
	Postcentral Gyrus	R	280	3.98	12	−34	82
	Superior Frontal Gyrus	R	344	3.94	18	8	56
	Middle Temporal Gyrus	L	784	3.74	−34	−66	14
		R	184	3.54	42	−58	20
	Supplementary Motor Area	L	848	3.73	−16	−14	60
		R	104	3.48	4	2	72
	Mid Cingulate	R	400	3.72	18	−20	38
		L	88	3.45	−10	−10	28
	Cerebellum	L	168	3.72	−8	−72	−30
	Putamen	R	144	3.39	24	8	6
	Insula	L	96	3.35	−28	20	6
	Amygdala	L	80	2.91	−20	−2	−24
Fearful > Neutral	Superior Parietal Gyrus	R	200	3.60	18	−80	50
Happy > Neutral	Supramarginal Gyrus	R	152	3.60	74	−20	16
	Ventral Striatum	R	240	2.93	6	8	−10
Motor-Visual > Rest
	Parahippocampal Gyrus	R	224	4.28	16	−18	−28
	Inferior Occipital Gyrus	R	200	4.03	40	−84	−16
	Angular Gyrus	R	80	3.56	52	−76	34
	Postcentral Gyrus	R	136	3.49	74	−2	18

Significant activations across whole-brain search are presented at p < 0.001, minimum cluster size of 10 voxels (80mm³). Activations shown in bold are within a priori ROIs, thresholded at p < 0.005.