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ENO mitigates hypoxia-induced pulmonary hypertension. Neonatal pigs were instrumented and ventilated as previously described (26). Pulmonary hypertension was induced by lowering the FiO2 to 14% (Hypoxia). (A) PAP; (B) MnBP; (C) PVR; (D) SVR; (E) PaO2; and (F) CO. Changes in PAP, PVR, and PaO2 are significant, whereas systemic effects are not evident. ●, 0.0025% ENO; ○, 0.025% ENO; and ▾, 0.125% ENO. *, Significantly different from hypoxia (P < 0.05).
