Table 1.
ENO administration in neonatal pigs (21% O2)
| Parameter | ENO % | Pre-compound | Compound | Post-compound |
|---|---|---|---|---|
| PAP, mmHg | 0.0025 | 12.4 (1.1) | 11.7 (1.2) | 13.3 (1.3) |
| 0.025 | 12 (1.1) | 10 (1.2) | 12.2 (1.6) | |
| 0.125 | 12.1 (1) | 9.8 (0.9)* | 13.7 (1.3) | |
| PVR, dynes/s/10−5 cm | 0.0025 | 3,004.1 (340.8) | 2,961.3 (295.9) | 3,500.4 (376.8) |
| 0.025 | 2,893.9 (322.7) | 2,628.4 (286.2) | 3,301.2 (440.8) | |
| 0.125 | 2,638.9 (314.6) | 2,409.1 (288.5) | 3,354.2 (384.2) | |
| PaO2, mmHg | 0.0025 | 74.2 (2.3) | 75.7 (3.4) | 74.5 (2.7) |
| 0.025 | 71 (1.9) | 73.7 (2.7) | 74.7 (0.8) | |
| 0.125 | 70 (2.4) | 72.5 (2.1) | 70 (5.5) | |
| MnBP, mmHg | 0.0025 | 48.5 (2.4) | 47.5 (3.4) | 47.5 (3.7) |
| 0.025 | 48.2 (3) | 48.7 (4.3) | 45.5 (4.1) | |
| 0.125 | 51.7 (4.3) | 47.5 (3.4) | 50.5 (4.4) | |
| SVR, dynes/s/10−5 cm | 0.0025 | 12,122.3 (1451) | 12,579.4 (1447.2) | 12,944.4 (1540.2) |
| 0.025 | 12,213.7 (1508.5) | 13,084.4 (1365.4) | 12,643.5 (1353.6) | |
| 0.125 | 11,342.8 (1442.6) | 11,676.4 (1268.6) | 12,316.9 (1323.3) | |
| CO, ml/min | 0.0025 | 438.8 (139.4) | 412.9 (115.2) | 410.4 (105.6) |
| 0.025 | 428.6 (128.3) | 397.7 (103.6) | 402.5 (103.4) | |
| 0.125 | 459.5 (140.6) | 429.7 (137.2) | 442.6 (140.4) |
Values are shown as mean (standard error). *, P < 0.05, as compared with pre-compound value.