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Transactivation of cathepsin K promoter constructs by Mitf and TFE3. The wild-type (WT) human cathepsin K promoter −928 bp to +2 (25, 26), mutant cathepsin K constructs with individual E-boxes mutated, and a deletion construct without the upstream three E-boxes were transfected into MCF-7 cells in the presence of Mitf, TFE3, or vector controls. The data are combined from three separate transfection experiments each performed in triplicates with bars indicating standard errors.
