Fig. 2.

Apolipoprotein E overexpression increases selective uptake of HDL cholesteryl esters into the liver. On day 4 after injection with the control adenovirus AdNull or with the human apolipoprotein E3-expressing adenovirus, AdhApoE3 kinetic experiments were performed using autologous HDL double labeled with ¹²⁵I-tyramine-cellobiose and ³H-cholesteryl ether (CE) as described in Materials and Methods. A: FCRs calculated from the respective plasma disappearance curves. B: Uptake of ¹²⁵I-tyramine-cellobiose and ³H-CE by the liver. Data are presented as means ± SEM. n = 6 mice for each condition. White bars, AdNull-injected mice; black bars, AdhApoE3-injected mice. * Significantly different from the respective AdNull-injected controls as assessed by Mann-Whitney U-test (at least P < 0.05).