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Mean PCSK9 levels in the three groups of untreated participants. The groups were categorized based on genetic FH mutation status and LDL-cholesterol level: the group where mutation was absent (control) and for FH heterozygotes, the untreated LDL-cholesterol percentile, either below the 75th percentile (FH low) or above the 90th percentile (FH high) for age and gender. Data were based on a model adjusted for age, sex, body mass index, and systolic blood pressure.
