Figure 4. Expression of Genes in the Cytoskeleton remodeling and keratin filament pathways were altered by PTU treatment.

Cytoskeleton structure in most eukaryotic cells consists of three distinct interconnected, filament systems: Actin filaments, Microtubules and intermediate filaments. Cell assembly is integrated by the network of intermediate filaments (IFs) and by their interactions with other cytoskeleton structural elements defining cytoarchitecture and cytodynamics. The IF network is critically involved in cell shape control and imparts intracellular mechanical strength. The experimental data are visualized on the map in red (increased expression or up-regulation) histogram. The height of the histogram corresponds to the relative expression value for a particular gene/protein.