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. 2012 Apr 18;7(4):e35213. doi: 10.1371/journal.pone.0035213

Figure 6. Representative histopathology of E18.5 calveria from vehicle, PTU and MMI treated mice.

Figure 6

Histopathologic analysis of coronal sections through the head of E18.5 embryos from dams treated with (A, D) vehicle, (B, E) PTU (100 mg/kg), or (C, F) MMI (20 mg/kg) from E7.5 to E9.5 did not reveal any significant morphologic changes in the bones of the calveria (arrowheads) or the connective tissue stroma within the (A, B, C) frontal or (D, E, F) parietal sutures when compared to the skulls of control embryos. Representative sections from (A, B, C) rostral dorsal frontal bone at the level of the nasal cortex, and (D, E, F) caudal dorsal parietal at the level of the ears. Scale bars = 200 µm. Masson's Trichrome stained sections are shown.