Table 2. Structural defects in E10.5 murine embryos.

Drug	Dose mg/kg	# of Embryos	Type of Defects			Total Sum of Defects
			Head folds not fused	Peri-cardial blood	Other defects	Embryo Defects	Odds Ratio	p-value
			n (%)	n (%)	n (%)	n (%)	OR (95% CI)
PTU	1	41	2 (4.8)	2 (4.4)	0 (0.0)	4 (9.7)	1.6 (0.5, 5.2)	0.24
	5	45	1 (2.2)	2 (4.2)	2 (4.2)	5 (11.1)	1.8 (0.6, 5.6)	0.15
	10	36	4 (11.1)	3 (8.1)	1 (2.7)	8 (22.2)	4.1 (1.5, 11.3)	0.0019
	25	73	3 (4.1)	6 (9)	3 (1.4)	12 (16.4)	2.8 (1.2, 6.9)	0.009
	50	53	3 (5.6)	6 (8)	0 (0)	9 (17)	2.9 (1.1, 7.7)	0.011
	100	140	18 (12.9)	13 (9.2)	5 (1.4)	36 (25.7)	4.9 (2.4, 10.5)	<0.0001
MMI	1	35	2 (5.7)	0 (0)	1 (2.5)	3 (8.6)	1.4 (0.4, 5.2)	0.33
	4	40	1 (2.5)	2 (5)	0 (0)	3 (7.5)	1.7 (0.3, 4.5)	0.41
	10	24	0 (0)	2 (8.3)	1 (4.2)	3 (12.5)	2.1 (0.5, 8.1)	0.15
	20	32	2 (6.2)	3 (9.3)	0 (0)	5 (15.6)	2.7 (0.8, 8.4)	0.04
Vehicle		154	3 (2)	7 (4.8)	0 (0)	10 (6.9)

Includes live embryos only.

Chi-square \ test.