Figure 6. Effects of Rh2 epimers and Ppd epimers on the transport of P-gp substrate digoxin across Caco-2 monolayers.

Cells were preincubated for 1 h in the presence of (A) 20(S)-Rh2 or 20(R)-Rh2, (B) 20(S)-Ppd or 20(R)-Ppd, and followed by co-incubation for 2 h in the presence of 5 µM digoxin. Data are the mean ± S.E. of three independent experiments. ^* p<0.05 vs control; ^** p<0.01 vs control; ^# p<0.05 between groups; ^## p<0.01 between groups.