Table 1. Pharmacokinetic parameters of digoxin after a single i.g. administration in the absence or presence of 20(S)-Rh2 or presence of 20(R)-Rh2 in rats.

Parameters	Digoxin (0.25 mg/kg i.g.)
	Control	20(S)-Rh2		20(R)-Rh2
		5 mg/kg	50 mg/kg	5 mg/kg	50 mg/kg
AUC 0–12 (nmol/L×h)	15.4±2.9	18.9±4.3	27.2±2.2* §§	34.9±6.0**	21.4±3.6 §
Cmax (nmol/L)	9.9±2.6	9.8±2.7	16.0±5.5* §	16.9±2.9*	10.3±3.3
t1/2 (h)	1.2±0.4	1.7±0.4	1.8±0.3	1.6±0.3	1.5±0.3
MRT0–12 (h)	1.7±0.6	2.7±0.8	2.2±0.4	2.3±0.3	2.0±0.3

^* p<0.05 vs control;

^** p<0.01 vs control;

^§ p<0.05 between Rh2 5 mg/kg group and Rh2 50 mg/kg group with the same configuration;

^§§ p<0.01 between Rh2 5 mg/kg group and Rh2 50 mg/kg group with the same configuration.