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. 2012 Apr 18;7(4):e35768. doi: 10.1371/journal.pone.0035768

Table 2. Pharmacokinetic parameters of ginsenoside Rh2 epimers and their deglycosylation metabolites Ppd epimers after i.g. administration of 25 mg/kg 20(S)-Rh2 or 20(R)-Rh2 in rats.

20(S)-Rh2 20(R)-Rh2 20(S)-Ppd 20(R)-Ppd
20(S)-Rh2 25 mg/kg
AUC 0-t (µg/L·min) 149888±40725 8648±1871 35129±2261 ND
MRT 0-t (min) 201±15 143±27 543±21 ND
Tmax (min) 207±15 126±42 520±48 ND
Cmax (µg/L) 572±162 17±2 85±7 ND
20(R)-Rh2 25 mg/kg
AUC 0-t (µg/L·min) 1193±230 13204±2322 ND ND
MRT 0-t (min) 132±26 279±19 ND ND
Tmax (min) 140±39 285±46 ND ND
Cmax (µg/L) 5±1 29±5 ND ND

ND, Not detected.