Table 2. Pharmacokinetic parameters of ginsenoside Rh2 epimers and their deglycosylation metabolites Ppd epimers after i.g. administration of 25 mg/kg 20(S)-Rh2 or 20(R)-Rh2 in rats.
20(S)-Rh2 | 20(R)-Rh2 | 20(S)-Ppd | 20(R)-Ppd | ||
20(S)-Rh2 25 mg/kg | |||||
AUC 0-t (µg/L·min) | 149888±40725 | 8648±1871 | 35129±2261 | ND | |
MRT 0-t (min) | 201±15 | 143±27 | 543±21 | ND | |
Tmax (min) | 207±15 | 126±42 | 520±48 | ND | |
Cmax (µg/L) | 572±162 | 17±2 | 85±7 | ND | |
20(R)-Rh2 25 mg/kg | |||||
AUC 0-t (µg/L·min) | 1193±230 | 13204±2322 | ND | ND | |
MRT 0-t (min) | 132±26 | 279±19 | ND | ND | |
Tmax (min) | 140±39 | 285±46 | ND | ND | |
Cmax (µg/L) | 5±1 | 29±5 | ND | ND |
ND, Not detected.