Table 3. The AUCs of ginsenoside Rh2 epimers and their deglycosylation metabolites Ppd epimers after incubation of ginsenoside 20(S)-Rh2 or 20(R)-Rh2 in rat fecal microflora.
Durg | 20(S)-Rh2 (nmol/L×h) | 20(R)-Rh2 (nmol/L×h) | 20(S)-Ppd (nmol/L×h) | 20(R)-Ppd (nmol/L×h) |
20(S)-Rh2 1 µM | 843.0±6.3 | 312.8±12.4 | 43363.1±2970.5 | ND |
20(S)-Rh2 10 µM | 9491.5±404.2 | 206.3±11.0 | 492692.9±11965.2 | ND |
20(R)-Rh2 1 µM | 202.9±8.7 | 1074.0±56.8 | 399.3±64.8 | 29655.9±2008.8 |
20(R)-Rh2 10 µM | ND | 55074.3±1394.1 | ND | 557984.8±6457.5 |
ND, Not detected.