Figure 6. CXCL12 and [N33A]CXCL12 transinhibit HER1 in 5637 or HeLa cells.

Both chemokines signal via G-proteins to calmodulin/calcineurin and modulate the ligand-dependent phosphorylation of HER1. CXCL12 induces a delay in the phosphorylation. [N33A]CXCL12, which is a G-protein-biased ligand, inhibits the HER1 phosphorylation.