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. 2001 May 1;98(10):5809–5814. doi: 10.1073/pnas.091102398

Figure 4.

Figure 4

Survival analysis of the CSQ and CSQ/βARKct mice treated with the β-blocker metoprolol. Kaplan–Meier survival analysis was used to determine the survival probability between the specified genotypes of mice while chronically treated with metoprolol in the drinking water. Mean survival age of the CSQ mice (n = 14) receiving no drug was 9 ± 1 weeks vs. 14 ± 2 weeks in the metoprolol-treated CSQ mice (n = 14; P < 0.0005). Mean survival age of the CSQ/βARKct mice (n = 31) receiving no drug was 15 ± 1 weeks vs. 24 ± 3 weeks in the metoprolol-treated CSQ/βARKct mice (n = 14; P < 0.0001). Curves for wild-type (n = 20) and βARKct (n = 13) mice treated with metoprolol are not shown but, collectively, they had only one death throughout the course of the study.