Table 4. Association Between Gene-specific Methylation and Cross-sectional Age and Change in Age Over Time in the Normative Aging Study, Boston, MA, 1999 - 2009.
| |
|
Unadjusted |
Adjusted b |
||||
|---|---|---|---|---|---|---|---|
| |
|
|
|
Full Cohort |
No IHD at Baseline |
||
| Gene | Change in % 5mC a | 95% CI | Change in % 5mC a | 95% CI | Change in % 5mC a | 95% CI | |
|
GCR |
Cross-sectional age |
-0.022 |
-0.073, 0.029 |
-0.031 |
-0.087, 0.025 |
-0.038 |
-0.104, 0.028 |
| |
Longitudinal age |
-0.151 |
-0.256, -0.046* |
-0.191 |
-0.321, -0.061* |
-0.212 |
-0.365, -0.059* |
|
iNOS |
Cross-sectional age |
-0.063 |
-0.133, 0.007 |
-0.097 |
-0.173, -0.022* |
-0.120 |
-0.212, -0.028* |
| |
Longitudinal age |
-0.660 |
-0.795, -0.526* |
-0.695 |
-0.860, -0.531* |
-0.661 |
-0.860, -0.462* |
|
ICAM |
Cross-sectional age |
-0.012 |
-0.029, 0.004 |
-0.010 |
-0.028, 0.008 |
-0.007 |
-0.028, 0.015 |
| |
Longitudinal age |
-0.030 |
-0.059, -0.002* |
-0.015 |
-0.051, 0.021 |
0.003 |
-0.041, 0.047 |
|
IL6 |
Cross-sectional age |
0.001 |
-0.101, 0.103 |
0.025 |
-0.083, 0.133 |
-0.002 |
-0.125, 0.122 |
| |
Longitudinal age |
-0.081 |
-0.198, 0.037 |
-0.064 |
-0.221, 0.094 |
-0.097 |
-0.277, 0.082 |
|
TLR2 |
Cross-sectional age |
0.016 |
0.004, 0.028* |
0.020 |
0.007, 0.032* |
0.015 |
-0.001, 0.030 |
| |
Longitudinal age |
-0.054 |
-0.078, -0.031* |
-0.033 |
-0.062, -0.004* |
-0.025 |
-0.060, 0.011 |
|
IFNγ |
Cross-sectional age |
-0.033 |
-0.080, 0.014 |
-0.040 |
-0.084, 0.005 |
-0.031 |
-0.081, 0.020 |
| |
Longitudinal age |
0.154 |
0.081, 0.227* |
0.110 |
0.021, 0.198* |
0.130 |
0.032, 0.229* |
|
F3 |
Cross-sectional age |
-0.002 |
-0.013, 0.008 |
-0.005 |
-0.017, 0.006 |
-0.001 |
-0.015, 0.012 |
| |
Longitudinal age |
0.040 |
0.017, 0.062* |
0.041 |
0.014, 0.068* |
0.055 |
0.023, 0.086* |
|
CRAT |
Cross-sectional age |
0.006 |
-0.003, 0.015) |
0.005 |
-0.005, 0.015 |
0.006 |
-0.006, 0.018 |
| |
Longitudinal age |
0.023 |
0.006, 0.039* |
0.036 |
0.015, 0.057* |
0.033 |
0.009, 0.058* |
|
OGG |
Cross-sectional age |
-0.006 |
-0.019, 0.007 |
-0.002 |
-0.016, 0.013 |
-0.004 |
-0.022, 0.015 |
| Longitudinal age | 0.084 | 0.055, 0.113* | 0.081 | 0.045, 0.116* | 0.088 | 0.045, 0.130* | |
% 5mC: % 5-methyl-cytosine; IHD: Ischemic Heart Disease * p < 0.05 a Change in % 5mC associated with a 1-y increase in cross-sectional age or longitudinal age b Adjusting for BMI, SBP, DBP, fasting blood glucose, % lymphocytes, % neutrophils use of statin, season, day of week, smoking status, and pack-years