Figure 5. Inhibition of RSA activity after pre-incubation of the S2 cells with different kinase inhibitors.

Cells were pre-incubated with three inhibitors (individually): 10 µM of SB203580 (p38 MAP kinase inhibitor), 50 µM of PD98059 [MAP kinase, (MEK) inhibitor] and 50 µM of AG490 (JAK inhibitor) for 1 h before exposure to 0.3 µM RSA for 24 h. Values are given as means ± SEM based on two independent repetitions. Values are followed by a different letter (a-c) are significantly different (post hoc Tukey-Kramer test with p = 0.05).