Figure 7. T-cadherin contributes to glucose tolerance, but not peripheral insulin sensitivity. (A) Submaximal hyperinsulinemic-euglycemic clamp demonstrating that 4 mo old male WT and KO mice are equally sensitive to insulin. (B and C) Intra-peritoneal glucose tolerance tests demonstrating an impaired glucose tolerance in KO compared with WT 5 mo old male C57Bl/6 mice (B) and 5 mo old male Black-Swiss mice (C). Solid line, WT. Hatched line KO. *p < 0.05, **p < 0.01, ***p < 0.001.