Figure 6. Inhibition of Ucp2 rescues GSIS in Bmal1^-/- islets. (A) Fold change over basal ATP/ADP ratio measured in isolated islets after exposure to increasing glucose concentrations and a rescue after exposure to 10 μM genipin for 30 min. n = 3–5 (ten islets each from three to five individual mice of each genotype). (B) Insulin secretion from isolated islets on exposure to increasing glucose concentrations and a rescue of insulin secretion after exposure to 10 μM genipin for 60 min. n = 3–5 (ten islets each from three to five individual mice of each genotype). All values are mean ± SEM *p ≤ 0.05.