| Antibiotic Associated Diarrhea (AAD), Traveller's Diarrhea (TD), and Infectious Diarrhea (ID) |
The primary outcome for AAD, TD, and ID is defined as diarrhea (3 loose stools/day for at least 2 days or 5 loose stools/48 h) within 2 months of antibiotic exposure. |
|
Clostridium difficile Disease (CDD) |
The primary outcome of CDD is defined as a new episode of diarrhea associated with a positive culture or toxin (A or B) assay within 1 month exposure to antibiotics. The outcome of prevention of CDD is a new episode of C. difficle positive diarrhea within 1 month of a previous CDD episode. |
| Irritable Bowel Syndrome (IBS) |
The primary outcome measures was the improvement in overall symptoms as defined by the presence or absence of the following physical symptoms: pain, flatulence, bloating, anxiety, and quality of life or the change in symptom scores from baseline. |
|
Helicobacter pylori (HPP) |
The primary outcome was the improvement of H. pylori eradication rates reducing side effects with probiotics. |
| Necrotizing Enterocolitis (NEC) |
The primary outcome of efficacy of probiotic supplementation in prevention of stage 2 or greater Necrotizing Enterocolitis, and safety in terms of blood culture-positive septis and any other adverse events reported by investigators. |
| Pouchitis (Pouch) |
The primary outcome of efficacy of probiotic supplementation was for the treatment of Pouchitis with no relapse. |
