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. 2012 Apr 18;7(4):e34897. doi: 10.1371/journal.pone.0034897

Table 2. Results of the meta-analysis on XRCC1 polymorphisms and childhood ALL risk.

Polymorphism Analysis Case/Control Additive model(aa vs AA) Dominant model(Aa+aa vs AA) Recessive model (aa vs AA+Aa)
OR[95% CI] P/P het OR[95% CI] P/P het OR[95% CI] P/P het
Arg399Gln Overall 880/1311 1.501[1.112, 2.026] 0.008/0.384 1.316[1.104, 1.569] 0.002/0.016 1.324[0.998, 1.757] 0.052/0.628
Asian 225/434 2.338[1.254, 4.359] 0.008/0.903 2.108[1.498, 2.967] 0.000/0.821 1.698[0.937, 3.077] 0.081/0.706
Caucasian 334/396 1.289[0.830, 2.000] 0.258/0.168 1.275[0.945, 1.722] 0.112/0.381 1.138[0.760, 1.704] 0.530/0.228
Mestizo 120/120 1.711[0.653, 4.479] 0.274/− 1.306[0.787, 2.169] 0.302/− 1.556[0.612, 3.954] 0.353/−
Mixed 201/361 1.227[0.629, 2.397] 0.548/− 0.845[0.597, 1.194] 0.339/− 1.358[0.707, 2.606] 0.358/−
Arg280His Overall 345/554 1.251[0.371, 4.220] 0.709/0.675 1.125[0.805, 1.574] 0.490/0.534 1.203[0.357, 4.055] 0.765/0.693
Asian 225/434 1.053[0.251, 4.426] 0.944/0.425 1.172[0.774, 1.775] 0.453/0.284 0.989[0.234, 4.175] 0.988/0.461
Mestizo 120/120 2.023[0.180, 22.720] 0.568/− 1.043[0.590, 1.843] 0.885/− 2.017[0.180, 22.545] 0.569/−
Arg194Trp Overall 783/1180 0.806[0.451, 1.438] 0.465/0.041 1.056[0.850, 1.312] 0.625/0.059 0.797[0.445, 1.426] 0.444/0.070
Asian 225/434 0.710[0.319, 1.578] 0.400/0.014 0.966[0.684, 1.363] 0.843/0.007 0.714[0.319, 1.600] 0.414/0.028
Caucasian 237/265 0.585[0.145, 2.351] 0.450/0.056 1.240[0.781, 1.969] 0.361/0.166 0.551[0.136, 2.233] 0.404/0.061
Mestizo 120/120 2.150[0.520, 8.885] 0.290/− 1.265[0.730, 2.190] 0.402/− 2.053[0.501, 8.405] 0.317/−
Mixed 201/361 0.443[0.049, 4.000] 0.469/− 0.929[0.586, 1.474] 0.755/− 0.446[0.050, 4.020] 0.472/−

OR Odds ratio; 95% CI 95% confidence interval.

a:minor allele; A:major allele.