Table 2. Results of the meta-analysis on XRCC1 polymorphisms and childhood ALL risk.
Polymorphism | Analysis | Case/Control | Additive model(aa vs AA) | Dominant model(Aa+aa vs AA) | Recessive model (aa vs AA+Aa) | |||
OR[95% CI] | P/P het | OR[95% CI] | P/P het | OR[95% CI] | P/P het | |||
Arg399Gln | Overall | 880/1311 | 1.501[1.112, 2.026] | 0.008/0.384 | 1.316[1.104, 1.569] | 0.002/0.016 | 1.324[0.998, 1.757] | 0.052/0.628 |
Asian | 225/434 | 2.338[1.254, 4.359] | 0.008/0.903 | 2.108[1.498, 2.967] | 0.000/0.821 | 1.698[0.937, 3.077] | 0.081/0.706 | |
Caucasian | 334/396 | 1.289[0.830, 2.000] | 0.258/0.168 | 1.275[0.945, 1.722] | 0.112/0.381 | 1.138[0.760, 1.704] | 0.530/0.228 | |
Mestizo | 120/120 | 1.711[0.653, 4.479] | 0.274/− | 1.306[0.787, 2.169] | 0.302/− | 1.556[0.612, 3.954] | 0.353/− | |
Mixed | 201/361 | 1.227[0.629, 2.397] | 0.548/− | 0.845[0.597, 1.194] | 0.339/− | 1.358[0.707, 2.606] | 0.358/− | |
Arg280His | Overall | 345/554 | 1.251[0.371, 4.220] | 0.709/0.675 | 1.125[0.805, 1.574] | 0.490/0.534 | 1.203[0.357, 4.055] | 0.765/0.693 |
Asian | 225/434 | 1.053[0.251, 4.426] | 0.944/0.425 | 1.172[0.774, 1.775] | 0.453/0.284 | 0.989[0.234, 4.175] | 0.988/0.461 | |
Mestizo | 120/120 | 2.023[0.180, 22.720] | 0.568/− | 1.043[0.590, 1.843] | 0.885/− | 2.017[0.180, 22.545] | 0.569/− | |
Arg194Trp | Overall | 783/1180 | 0.806[0.451, 1.438] | 0.465/0.041 | 1.056[0.850, 1.312] | 0.625/0.059 | 0.797[0.445, 1.426] | 0.444/0.070 |
Asian | 225/434 | 0.710[0.319, 1.578] | 0.400/0.014 | 0.966[0.684, 1.363] | 0.843/0.007 | 0.714[0.319, 1.600] | 0.414/0.028 | |
Caucasian | 237/265 | 0.585[0.145, 2.351] | 0.450/0.056 | 1.240[0.781, 1.969] | 0.361/0.166 | 0.551[0.136, 2.233] | 0.404/0.061 | |
Mestizo | 120/120 | 2.150[0.520, 8.885] | 0.290/− | 1.265[0.730, 2.190] | 0.402/− | 2.053[0.501, 8.405] | 0.317/− | |
Mixed | 201/361 | 0.443[0.049, 4.000] | 0.469/− | 0.929[0.586, 1.474] | 0.755/− | 0.446[0.050, 4.020] | 0.472/− |
OR Odds ratio; 95% CI 95% confidence interval.
a:minor allele; A:major allele.