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Pharmacokinetic parameter estimates derived for 6 healthy beagle dogs administered fenoldopam at 0.8 μg/kg/min intravenously for 180 minutes. Shown for each dog are the fenoldopam concentrations measured at 150 minutes after drug infusion start (C150) and the weight normalized clearance calculated from the C150 (assuming steady state had been reached) and drug infusion rate.
| DOG | C150 (ng/mL) | CLEARANCE (mL/min/kg) |
|---|---|---|
| 1 | 11 | 75 |
| 2 | 29 | 28 |
| 3 | 54 | 15 |
| 4 | 8 | 97 |
| 5 | 8 | 98 |
| 6 | 16 | 50 |
| Mean (SD) | 21 (18) | 60 (35) |
