Table 2.
Cardiac, respiratory, and vascular parameters measured from 6 healthy dogs administered fenoldopam at 0.8 μg/kg/min intravenously for 180 minutes. Data at each time point after infusion start were averaged. Normal heart rate: 70–120 bpm. Normal respiratory rate: 16–30 br/min. Normal systolic blood pressure: 80–160 mmHg.
| TIME (minute) | Mean (SD) HR (bpm) | Mean (SD) RR (br/min) | Mean (SD) systolic BP (mmHg) |
|---|---|---|---|
| 0 | 98.3 (13.4) | 22.3 (3.7) | 110.5 (16.7) |
| 5 | 98.7 (14.5) | 22.8 (5.2) | 119.4 (6.6) |
| 10 | 96.7 (17.2) | 25.0 (6.9) | 112.6 (11.3) |
| 20 | 100.0 (16.0) | 23.0 (6.7) | 115.6 (13.6) |
| 30 | 99.0 (20.4) | 26.0 (7.0) | 119.8 (10.7) |
| 60 | 93.3 (10.3) | 22.0 (5.5) | 119.6 (9.3) |
| 90 | 84.7 (8.2) | 22.0 (8.4) | 120.1 (10.4) |
| 120 | 93.3 (15.3) | 19.7 (5.4) | 112.6 (8.4) |
| 150 | 91.0 (6.4) | 16.7 (4.5) | 118.6 (10.6) |
| 180 | 86.3 (8.6) | 15.7 (4.8) | Not taken |
| 182 | 82.0 (10.7) | 18.7 (4.1) | Not taken |
| 185 | 76.7 (13.7) | 19.0 (5.9) | Not taken |
| 190 | 80.7 (12.2) | 18.7 (2.1) | 115.8 (12.3) |
| 195 | 76.7 (10.9) | 18.0 (4.9) | 115.3 (10.9) |
| 210 | 80.0 (8.4) | 22.0 (5.1) | 117.1 (12.8) |
| 225 | 76.7 (12.2) | 19.3 (4.3) | 115.8 (12.9) |
| 240 | 79.3 (13.5) | 18.0 (4.2) | 117.5 (13.4) |
| 270 | 83.3 (6.9) | 19.7 (2.7) | 116.9 (11.1) |
| 300 | 82 (12.8) | 17.0 (2.8) | 119.6 (11.3) |
bpm = beats per minute
br/min = breaths per minute
mmHg = millimeters of mercury