Table 1.
Demographic, psychiatric, medical, and HIV-disease characteristics of the study groups.
| HIV−
|
HIV+
|
p | Groupa | |||
|---|---|---|---|---|---|---|
| Younger (n = 93) | Older (n = 51) | Younger (n = 50) | Older (n = 63) | |||
| Demographic Characteristics | ||||||
| Age (years) | 32.2 (5.2) | 56.8 (4.9) | 32.8 (4.0) | 58.2 (6.2) | <0.001 | Y− = Y+ < O− = O+ |
| Education (years) | 14.0 (2s.2) | 13.4 (2.3) | 14.2 (1.9) | 13.9 (2.6) | 0.390 | ----- |
| Ethnicity (% Caucasian) | 66.7% | 78.4% | 62.0% | 74.6% | 0.218 | ----- |
| Sex (% male) | 68.8% | 74.5% | 78.0% | 82.5% | 0.249 | ----- |
| Estimated Verbal IQb | 103.4 (10.1) | 100.1 (12.0) | 103.2 (8.7) | 101.5 (11.7) | 0.282 | ----- |
| Psychiatric Characteristics | ||||||
| Total Mood Disturbance (POMS)c | 41.0 (22.8, 73.3) | 40.0 (17.0, 81.0) | 54.0 (30.0, 79.0) | 62.0 (46.8, 91.5) | 0.006 | Y−, O− < O+ |
| POMS Depression/Dejection | 4.0 (1.0, 14.0) | 4.0 (1.0, 18.0) | 6.0 (2.0, 16.0) | 9.0 (4.0, 17.0) | 0.160 | ----- |
| Medical Characteristics | ||||||
| Hepatitis C Virus (% infected) | 5.1% | 37.5% | 7.3% | 25.0% | <0.001 | Y− = Y+ < O− = O+ |
| Vascular Risk (%) | 10% | 41% | 18% | 43% | <0.001 | Y− = Y+ < O− = O+ |
| HIV Disease Characteristics | ||||||
| Duration of Infection (years) | ----- | ----- | 4.6 (4.5) | 10.7 (6.5) | <0.001 | Y+ < O+ |
| Proportion with AIDS (%) | ----- | ----- | 32.0% | 71.0% | <0.001 | Y+ < O+ |
| Proportion on ARVs (%) | ----- | ----- | 37.5% | 76.7% | <0.001 | Y+ < O+ |
| Nadir CD4c (cells/μl) | ----- | ----- | 282.0 (170.3, 463.5) | 153.0 (50.0, 227.0) | <0.001 | Y+ > O+ |
| Current CD4c (cells/μl) | ----- | ----- | 432.0 (273.5, 623.5) | 419.0 (271.0, 596.8) | 0.564 | ----- |
| Plasma HIV RNAc (log10) | ----- | ----- | 3.9 (2.6, 4.7) | 2.6 (1.7, 2.9) | <0.001 | Y+ > O+ |
Note. Means (SD) unless otherwise noted. HIV = Human Immunodeficiency Virus; Y = younger (< 40 years); O = older (≥ 50 years). POMS = Profile of Mood States; AIDS = Acquired Immune Deficiency Syndrome; ARVs = antiretroviral therapies; CD4 = Cluster of Differentiation 4; CSF = Cerebrospinal Fluid;
a
p < 0.05;
b
Based on the Reading subtest from the Wide Range Achievement Test, Revision 3;
c
Median (interquartile range).