Table 2.
Selected Sensitivity & Specificity for AUT, PDD-NOS & Combined Cases for 3 Porphyrin Measure
| Test Criteria | Control | Autism | PDD-NOS | Combined | Case/Control |
|---|---|---|---|---|---|
| Penta Criteria: | Urinary Penta > 2.1 nmol/gCr | ||||
| True Positive (Sensitivity) | 9 (30%) | 5 (36%) | 14 (32%) | Cases | |
| False Negative (1-Sensitivity) | 21 (70%) | 9 (64%) | 30 (68%) | ||
| True Negative (Specificity) | 30 (94%) | Controls | |||
| False Positive (1-Specificity) | 2 (6%) | ||||
| Total | 32 | 30 | 14 | 44 | |
| Copro Criteria: | Copro > 108 nmol/gCr | ||||
| True Positive (Sensitivity) | 10 (33%) | 2 (14%) | 7 (16%) | Cases | |
| False Negative (1-Sensitivity) | 20 (67%) | 12 (86%) | 37 (84%) | ||
| True Negative (Specificity) | 30 (94%) | Controls | |||
| False Positive (1-Specificity) | 2 (6%) | ||||
| Total | 32 | 30 | 14 | 44 | |
| Z-Score Combined Criteria: | Z-Penta + Z-Copro > 1.13 | ||||
| True Positive (Sensitivity) | 10 (33%) | 3 (21%) | 13 (30%) | Cases | |
| False Negative (1-Sensitivity) | 20 (67%) | 11 (79%) | 31 (70%) | ||
| True Negative (Specificity) | 32 (100%) | Controls | |||
| False Positive (1-Specificity) | 0 | ||||
| Total | 32 | 30 | 14 | 44 | |