Table 2.
Birth weight and gestational age by study among infants born to HIV-infected mothers, 1989–2007, Blantyre, Malawi
| Study | Birth weight (g) | Low birth weight (<2500 g at birth) |
Gestational age (weeks) | Preterm birth (<37 weeks GA) |
LBW among full-term infants (<2500 g and ≥37 weeks gestational age at birth) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean ± SE | P-valuea | n | % | P-valuea | N | Mean ± SE | P-valuea | n | % | P-valuea | n | % | P-valuea | |
| ICAR | 656 | 2795.5 ±23.8 | 0.93 | 141 | 21.5 | 0.64 | 648 | 38.1 ±0.1 | <0.001 | 97 | 14.9 | 0.81 | 38 | 5.9 | 0.79 |
| PAVE | 244 | 2793.0 ±34.6 | 52 | 21.3 | 236 | 38.1 ±0.3 | 34 | 14.0 | 17 | 7.0 | |||||
| PIP | 2142 | 2825.8 ±11.1 | 427 | 19.9 | 2140 | 37.8 ±0.05 | 298 | 13.9 | 127 | 5.9 | |||||
| HPTN | 417 | 2881.3 ±28.9 | <0.001 | 74 | 17.8 | <0.001 | 405 | 38.3 ±0.1 | <0.001 | 53 | 12.9 | <0.001 | 15 | 3.7 | 0.01 |
| NVAZ | 2020 | 3078.7 ±9.1 | 103 | 5.1b | 2020 | 39.0 ±0.1 | 27 | 1.3b | 76 | 3.8 | |||||
| PEPI | 3395 | 3010.4 ±7.8 | 349 | 10.3 | 3395 | 38.6 ±0.03 | 166 | 4.9 | 183 | 5.4 | |||||
| Total | 8874 | 2953.4 ±5.3 | 1146 | 12.9 | 8844 | 38.5 ±0.03 | 675 | 7.6 | 456 | 5.2 | |||||
HIVNET=HIV Network; HPTN=HIV Prevention Trials Network; GA=gestational age; ICAR=International Collaboration for AIDS Research; LBW=low birth weight; NVAZ=Nevirapine and Zidovudine; PAVE=Preparation for AIDS Vaccine Evaluation; PIP= Perinatal Infection Project; PEPI=Post-exposure Prophylaxis of Infants; SE=standard error
a
P values compare means and proportions across the three studies within each time period (earlier and later studies). Kruskal Wallis test used for means. Chi-square test used for proportions.
b
Preterm infants and infants with very low birth weight excluded from study per protocol.