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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Circ Arrhythm Electrophysiol. 2012 Mar 9;5(2):371–379. doi: 10.1161/CIRCEP.111.969493

Figure 4.

Figure 4

Ranolazine eliminates late phase 3 early afterdepolarizations (EADs) and delayed afterdepolarizations (DAD)-induced triggered activity in superior vena cava sleeve preparations. A: ACh (1 μM) and high calcium (5.4 mM)- induce prominent late phase 3 EADs at basic cycle length (BCL) of 2000 ms following a train of 20 beats at BCL 200 ms (not shown). B: Addition of ranolazine (10μM) eliminates late phase 3 EADs. C. Isoproterenol (Iso, 1 μM) and high calcium (5.4 mM) induce a triggered response followed by a DAD following pacing at BCLs of 100 and 90 ms and 2 triggered beats followed by a DAD at BCL of 80 ms. D. Addition of ranolazine (5 μM) eliminates the triggered beats but DADs persisted.