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Influence of cholesterol depletion on the secretion of APPsα from HEK and HEK ADAM 10 cells. (A) Cells were incubated in the presence of 10 mM MβCD for 30 min (lanes 2 and 4). After 4 h, the medium was collected, and proteins were precipitated and subjected to immunoblot analysis with the antibody 6E10 followed by a 35S-labeled anti-mouse IgG antibody. (B) Quantitative analysis of secreted APPsα. Bars indicate mean ± SD (n = 4). **, P < 0.001 (Student's t test).
