. 2001 Apr 17;98(10):5815–5820. doi: 10.1073/pnas.081612998

Table 1.

Effect of lovastatin on APPsα secretion in different cell lines

Cell line	APPsα (% of control)
HEK 293	272 ± 46^*
HEK ADAM 10	190 ± 20^**
U373	151 ± 7^**
H4	139 ± 4^**
SH-SY5Y (APP_751/770)	171 ± 4^**
SH-SY5Y (APP₆₉₅)	221 ± 9^**

Cells were cultured in DMEM supplemented with 10% lipid-deficient serum and 1 μM lovastatin for 20 h. After 4 h, the medium was collected, and APPsα was determined as described. Control cells were cultured without lovastatin.

Data are expressed as percentage of control and represent the mean ± SD for three independent determinations. *, P < 0.005; **, P < 0.001 (Student's t test).