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Apparent KI values of JSM6427 and CRRETAWAC for wild-type and chimaeric α5β1-1 integrins
| JSM6427 | CRRETAWAC | |||
|---|---|---|---|---|
| integrin | 70K | 50K | 70K | 50K |
| huα5β1-1 | ND | 0.65 ± 0.15 | ND | 47 ± 9 |
| zfα5(huW1-W4)β1-1 | ND | 0.75 ± 0.04 | ND | 31 ± 12 |
| zfα5(SWAA)β1-1 | 7.2 ± 2.4 | ND | 126 ± 43 | ND |
| Triple swap | 1.21 ± 0.04 | ND | 76 ± 20 | ND |
Apparent KI values (nM) for 70K fragment of zebrafish fibronectin or 50K fragment of human fibronectin binding to recombinant integrins. Values are mean ± S.D.; n=3-6 experiments. ND: not determined.
