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. 2012 Mar 25;2012:249219. doi: 10.1155/2012/249219

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Copyright © 2012 Joanna Przybyl et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Targets of SS18-SSX1/2 fusion oncoproteins involved in cell growth and proliferation, TP53 pathway, chromatin remodeling, and cytoskeleton remodeling, which may contribute to synovial sarcoma tumorigenesis. COM1-candidate of metastasis protein 1; PcG-polycomb group proteins; EGR-early growth response protein 1; mSIN3A-transcriptional regulator; HDAC-histone deacetylase complex; hBRM/hSNF2α-chromatin remodeling complex; TP53-tumor protein p53; HDM2-Mdm2 p53 binding protein homolog (mouse); XRCC4-X-ray repair complementing defective repair in Chinese hamster cells 4; IGF2-insulin-like growth factor 2; IGF-1R-insulin-like growth factor 1 receptor; BCL-2-B-cell CLL/lymphoma 2. *Only COM1 and mSIN3A have been described to interact directly with SS18-SSX1/2 fusion proteins.