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The radiocarcinogenic model. Schematic representation of the radiocarcinogenic osteosarcoma mouse model showing that 4-week old mice weekly receive low-dose injections of 45Ca intraperitoneally (i.p.) for four weeks. Within 8–12 months, all female mice develop osteosarcomas. Most lesions are located in the spines of the animals, and metastases are not frequently found. Please note that this figure is based on oral communication with Professor Thomas.
