Table 6.
Clinically relevant differences between health states.
| Health state comparisons | EQ-5D (mean utility) | QLQ-C30 (mean global QoL) | ||
|---|---|---|---|---|
| Difference | Clinically relevant difference1 | Difference | Clinically relevant difference2 | |
| 1st-line CT (HS 1) versus 2nd-line CT (HS 2) | 0.08 | Positive | 7.46 | Little change |
| 1st-line CT (HS 1) versus 3rd-line CT (HS 3) | −0.05 | None | 7.84 | Little change |
| 2nd-line CT (HS 2) versus 3rd-line CT (HS 3) | −0.14 | Negative | 0.38 | No change |
| Progressive disease (HS 4) versus Off CT, preprogression (HS 5) | −0.21 | Negative | −30.26 | Very much change |
Note: 10.074 difference in mean utility, 2“little change” (5–10 points change in the score), a “moderate change” (10–20 points), and “very much change” (>20 points).