Figure 3.

Proposed model for the action of mancozeb in S. cerevisiae cells. This model results from the integration of yeast chemogenomics (Dias et al., 2010) and proteomics (Santos et al., 2009) approaches. The complex mancozeb-induced expression changes and mancozeb determinants of yeast resistance, were found to be related to oxidative stress, V-ATPase function, protein translation initiation and protein folding, disassembling of protein aggregates and degradation of damaged proteins, lipid and ergosterol biosynthesis, mitochondrial function, cell wall remodeling, and multidrug resistance transporters.