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. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: J Med Chem. 2012 Apr 3;55(7):3535–3545. doi: 10.1021/jm300214e

Figure 4.

Figure 4

Virological effects of the indole enantiomers, 9g and 9h, in mice with acute NSV encephalomyelitis. Cohorts of NSV-infected mice were treated with 9g or 9h (30 mg/kg/dose) or with a vehicle control by intraperitoneal injection every 12 hours beginning 12 hours after virus challenge. At 24-hour intervals, viral titers were measured in quadruplicate brain (A) and spinal cord (B) tissue samples from each group by plaque titration assay. Statistical differences (*p<0.05) in tissue viral loads were determined by an unpaired Student’s t-test compared to vehicle-treated controls.