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. Author manuscript; available in PMC: 2013 Apr 12.
Published in final edited form as: J Med Chem. 2012 Apr 3;55(7):3535–3545. doi: 10.1021/jm300214e

Scheme 2.

Scheme 2

Preparation of Indole Analogs of 1a

aReagents and Conditions: (a) K2CO3, DMF, R1Cl, 60 °C. (b) LiOH, aq THF, 60 °C. (c) ethyl isonipecotate, EDC, HOBt, DIEA, DMF, RT. (d) HNR2R3, EDC, HOBt, DIEA, RT.