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. 2012 Mar 28;32(13):4651–4659. doi: 10.1523/JNEUROSCI.3308-11.2012

Figure 7.

Figure 7.

BDNF-induced and fear conditioning-induced histone modifications around the Homer1 promoter. ChIP assays were performed to measure the levels of several histone modifications around the Homer1 promoter after fear conditioning and BDNF-induced plasticity. Levels of promoter enrichment were quantified by QT-PCR. a, Histone H3 acetylation, an enhancive marker of transcription, was strongly increased at the Homer1 promoter after BDNF-induced plasticity in hippocampal cells (*p < 0.01, n = 6/group) b, Histone H3 acetylation was also increased at the Homer1 promoter in the hippocampus after fear conditioning (*p < 0.05, n = 10/group). Histone H4 acetylation, H3K9 methylation, and H3K27 methylation were not altered after BDNF-induced plasticity or fear conditioning. c, Histone H3K9 methylation, a repressive marker of transcription, was strongly decreased after BDNF-induced plasticity at the Homer1 promoter in amygdala cells (*p < 0.05, n = 6/group). d, Histone H3K9 methylation was also decreased after fear conditioning in the amygdala (*p < 0.01, n = 6/group). Significant changes in acetylation or methylation were not detected at the GAPDH promoter region (data not shown).