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. Author manuscript; available in PMC: 2012 Apr 19.
Published in final edited form as: Chem Rev. 2009 Sep;109(9):4092–4107. doi: 10.1021/cr800551w

Figure 1.

Figure 1

An interpretation of the standard binding free energy. Upon binding, the volume available to the ligand is changed from V∘ to Vb. At the same time, the ligand gains interaction energy W0.