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. Author manuscript; available in PMC: 2012 Apr 19.
Published in final edited form as: Chem Rev. 2009 Sep;109(9):4092–4107. doi: 10.1021/cr800551w

Figure 4.

Figure 4

(A) A receptor (orange) and ligand (green) connected by a linker (black), showing the position vector, r, relating the ligand to the receptor, and the orientation of the ligand in space ω. In the bound state r takes the value r0. (B) Binding of a bivalent ligand can be viewed as the sequential binding of the first fragment followed by intramolecular binding of the second.