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. Author manuscript; available in PMC: 2012 Sep 14.
Published in final edited form as: Sci Transl Med. 2011 Sep 14;3(100):100ra88. doi: 10.1126/scitranslmed.3001909

Fig. 5.

Fig. 5

Up-regulation of RGS2 and RGS3 in canine models of resynchronization and human responders to chronic CRT. (A and B) Western blots (A) and summary densitometry (B) for protein expression of RGS2, RGS3, and RGS4 (n = 4 to 5 per group). Analysis is normalized to GAPDH as a loading control. *P < 0.001 versus control (Con); P < 0.01 versus HFdys and HFsyn; †P < 0.01 versus control; P < 0.001 versus HFdys and HFsyn; #P < 0.001 versus all other groups. (C) Enhanced RGS2 and RGS3 mRNA expression is present in human LV biopsy samples from responder (R) patients, whereas it is absent in nonresponders (NR). Responders also demonstrated a significant decline in myocardial B-type natriuretic peptide (BNP). Differential response in EF is also displayed for the two groups.