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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jan 4;22(7):2635–2639. doi: 10.1016/j.bmcl.2011.12.123

Scheme 1.

Scheme 1

Reagents and conditions: aNH3 (l), −33 °C, 10 h, 100%; bPOCl3 (7.75 eq.), toluene, reflux, 5 h, 88%; cBnO2CCH2NH3•OTs, Et3N, DMF, 60 °C, 16 h, 90%; dH2NOH•HCl (3.7 eq.), Et3N, EtOH, −10°C, 4 h, 98%.