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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Bioorg Med Chem Lett. 2012 Jan 4;22(7):2635–2639. doi: 10.1016/j.bmcl.2011.12.123

Scheme 2.

Scheme 2

Reagents and conditions: aHCO2−H4N+, Pd/C (10%), EtOH, 86% (Cl:H, 1:4); bH2NOH•HCl, Et3N, EtOH, rt, 12 h, 88%; cAlMe3 (2 eq.), NH4Cl (2 eq.), toluene, 80 °C, 32 h, 95%; dBnO2CCH2NH3+ TsO−, Et3N, DMF, 60 °C, 48h, 17%.