Table 1. Sub-set of molecules tested for cardioprotection in perfused hearts.

The full list of 37 most protective molecules is in Online Table II. Six of those were tested in perfused hearts, as listed above. In addition, one molecule that was without effect (propoxur), and 3 which exhibited a detrimental effect in the screen, were tested. Molecules are listed in the order they were tested.

Score	Compound	Structure	Mw*	LogP	Bioactivity, notes, references
0.546	Dioxybenzone		244.2	2.34	UVA/UVB Blocker
0.580	Cloxyquin		179.6	2.29	Antimycobacterial. Similar to clioquinol, a Zn chelator which stimulates autophagy 25 and uncouples mitochondria 51
0.732	Methapyrilene		261.4	3.41	Antihistamine, anticholinergic, sedative
0.581	Mevastatin		390.5	3.35	Cholesterol lowering agent. Protects cardiomyocytes from IR injury via GSK-3β inhibition2 31.
0.687	Clorsulon		380.7	0.58	Antifilarial, used w. ivermectin. Phosphoglycerate kinase inhibitor 36.
0.778	7-Hydroxyflavone		238.2	2.68	Vasorelaxant, possibly via KCa channels 39.
1.003	Propoxur		209.3	1.53	Insectiside, cholinesterase inhibitor. Elicits pressor response in-vivo 52
2.040	Allopregnanolone		304.5	3.99	Neurosteroid. GABAA receptor agonist. Anesthetic (eltanolone 53, minaxolone 54)
2.103	Apiin		562.5	−0.98	Flavonoid glycoside from parsley.
1.850	2,4-Dichloro phenoxybutyrate		249.1	2.86	Herbicide (2,4-DB) metabolized to 2,4-D (Agent Orange)