Table 1.

Efficacy and Safety of Treatment with Dexmedetomidine and Midazolam^*

Outcome	Dexmedetomidine (n = 244)	Midazolam (n = 122)	p value
Time within target RASS range (mean %)	77.3	75.1	0.18
Duration of mechanical ventilation (days) (median and 95% CI)	3.7 (3.1–4.0)	5.6 (4.6–5.9)	0.01
Duration of ICU stay (days) (median and 95% CI)	5.9 (5.7–7.0)	7.6 (6.7–8.6)	0.24
% of patients with delirium episodes	54.1	76.6	<0.001
% of patients requiring open-label midazolam	62.7	49.2	0.02
% of patients with hypertension episodes requiring intervention	18.9	29.5	0.02

CI = confidence interval, ICU = intensive care unit, RASS = Richmond Agitation–Sedation Study.

^*Data from the SEDCOM study.⁸