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Complex III dysfunction also leads to enhanced ROS and Aβ levels. (A) Levels of superoxide anion radicals (DHE MFI normalized on untreated controls) were significantly increased after the treatment with antimycin (100 μM) for 30, 60, and 120 min. (B) Soluble Aβ1-40 levels in HEK cells are significantly increased after 24-h insult with antimycin (100 μM) compared to cells without antimycin. (A, B) n=6±SEM; unpaired t-test; *p<0.05, ***p<0.001.
